All of the "surprising" stuff they do is because they reduce neuroinflammation. Imo. As far as I can tell from the literature.
I'm fairly sure that part of the reason they reduce neuroinflammation is because of pulmonary GLP-1 mechanisms. (Lung and brain are quite intimately connected, as is inflammation to the other two. As well as the gut. And… metabolism.)
Neuroinflammation is very behavior-modifying.
(Neuroinflammation kind of makes sense as an untamperable side-channel of information for neuronal processes – out of band; Protective. Can't think yourself to death.)
There's tons of papers to read. You wouldn't believe how much accurate and correct and actionable and predictive scientific information exists that nobody reads.
Read primary sources. Anyone can read. Don't let anyone tell you that you can't read. Least of all yourself.
Do you have any recommendations for literature you like? (My experience in eye science matches yours - the literature is WAY ahead of what people believe)
Why do you suggest the drop in violent behavior is a byproduct of neuroinflammation reduction, as opposed to being a byproduct of anhedonia which seems more obvious to me?
(and having had twice the experience of autoimmune related illnesses making people close to me very aggressive until diagnosed and treated; and it was 1:1 always with things that made inflammation go up, aggression went up. In retrospect. And the opposite: things that reduced aggression always have an inflammation-reducing aspect)
n=1, tirzepatide puts my brain into "neutral," [1] I do not have strong feelings anymore on most anything not "fight or flight." Ego death via GLP-1 if you will. Probably has something to do with how it patches the reward center and its link to impulsive behavior in the prefrontal cortex [2].
It is kind of interesting the implications of "making you feel less hungry" in terms of a general insensitivity to the bodies own signalling mechanisms, vs just a hyper convenient targeted approach that only strikes the hunger portion of the dopamine-reward mechanism.
I wonder if you can do a simple experiment between glp and non glp users where you try and measure various biological response to giving someone say $20?
Going further I wonder if it affects other responses like pain response. How long might you keep your hand on a plate warming up? I seem to remember that sort of experimental setup in my undergrad days of signing up for every psychology department experiment under the sun for beer money.
They're FDA approved drugs, so it's a matter of when they're covered by any given prison's health plan. They're unlikely to be given off-label, But there's probably plenty of prisoners on GLPs at least for diabetes if not weight control.
I only mean offer it to them for free so they don't have to sneak in with the assorted peptides and other compounds. Many body builders have already been using Retatrutide for a couple years for muscle definition even though it is not yet approved. I would be quite surprised if they were not already sneaking it into the prison system. Government funded, sourced and dosed should be somewhat safer than going to sketchy websites that require bitcoin and no guarantees of purity.
If I were a prison guard or warden I would be happy to encourage prisoners to use any compound that may improve their impulse control which is likely one of the root causes of their incarceration in the first place.
Tell that to the many prisoners who participated in and benefited from HIV and hepatitis vaccine trials. What a travesty it would have been if there were a blanket ban on prisoner research.
Research on prisoners is subject to stricter standards, though. From the HHS website:
> Research involving prisoners is permissible only if the research involves one or more of four permissible categories, or if the research meets the criteria described in an HHS Secretarial waiver that applies to certain epidemiological research [...]
> (i) the study of the possible causes, effects, and processes of incarceration, and of criminal behavior, and
> (ii) the study of prisons as institutional structures or of prisoners as incarcerated persons. [...]
> (iii) research on conditions particularly affecting prisoners as a class; [...]
> (iv) research on practices, either innovative or accepted, which have the intent and reasonable probability of improving the health or well-being of the subject. [...]
The SS's policy towards the interred was heavily inspired by the policies the United States was already famous for. We have a historically monstrous record of unethical medical testing against both interred and underprivileged populations.
Nothing wrong with making GLP-1s freely available to all who want them if it improves metabolic health, reduces addiction, reduces cancer and inflammation risk, etc. Side effects are known and data to date shows risks are low. Ship it to everyone who wants it imho and kick off the longitudinal study.
The aggregate potential benefit is so high and the risk and cost reasonably low. Certainly, no one should ever be forced to take it, or be experimented on without their explicit, informed consent (and "experimented on" in this context is "taking the GLP-1 already and we're just tracking the outcomes at scale").
Honestly, I look forward to not having to worry in the back of my mind about having to deal with some unhinged person's "force of will" when I'm just trying to get groceries or pick my kid up from school. A calmer, more cooperative, less "assertive/aggressive" population is a good thing if that's really a possible outcome of these drugs.
This is a known potential side-effect of these drugs. When I started them my doctor warned me about a possible lack of motivation. These drugs trigger your body's satiation mechanism (as I understand them–not a doctor) and that can apply to more things than just eating.
All of the "surprising" stuff they do is because they reduce neuroinflammation. Imo. As far as I can tell from the literature.
I'm fairly sure that part of the reason they reduce neuroinflammation is because of pulmonary GLP-1 mechanisms. (Lung and brain are quite intimately connected, as is inflammation to the other two. As well as the gut. And… metabolism.)
Neuroinflammation is very behavior-modifying.
(Neuroinflammation kind of makes sense as an untamperable side-channel of information for neuronal processes – out of band; Protective. Can't think yourself to death.)
There's tons of papers to read. You wouldn't believe how much accurate and correct and actionable and predictive scientific information exists that nobody reads.
Read primary sources. Anyone can read. Don't let anyone tell you that you can't read. Least of all yourself.
Do you have any recommendations for literature you like? (My experience in eye science matches yours - the literature is WAY ahead of what people believe)
Why do you suggest the drop in violent behavior is a byproduct of neuroinflammation reduction, as opposed to being a byproduct of anhedonia which seems more obvious to me?
Good question!! thank you!
Because of this paper: https://www.frontiersin.org/journals/behavioral-neuroscience...
(and having had twice the experience of autoimmune related illnesses making people close to me very aggressive until diagnosed and treated; and it was 1:1 always with things that made inflammation go up, aggression went up. In retrospect. And the opposite: things that reduced aggression always have an inflammation-reducing aspect)
A hungry man is an angry man.
Ehhh. An angry man is an angry man. An angry, hungry man is extra angry.
It's only a matter of time before nootropics forums start experimenting with these drugs...
These drugs seem to change something fundamental that reduces problematic behavior.
The sorts of people who are on nootropics forums are definitely already experimenting with GLP-1 agonists and have been for a long time now.
What if you can't reduce problematic behavior without also reducing desirable behavior (like motivation)?
n=1, tirzepatide puts my brain into "neutral," [1] I do not have strong feelings anymore on most anything not "fight or flight." Ego death via GLP-1 if you will. Probably has something to do with how it patches the reward center and its link to impulsive behavior in the prefrontal cortex [2].
[1] https://www.youtube.com/watch?v=SSEjPuR11_k
[2] Diekhof EK, Nerenberg L, Falkai P, Dechent P, Baudewig J, Gruber O. Impulsive personality and the ability to resist immediate reward: an fMRI study examining interindividual differences in the neural mechanisms underlying self-control. Hum Brain Mapp. 2012 Dec;33(12):2768-84. doi: https://doi.org/10.1002/hbm.21398 Epub 2011 Sep 21. PMID: 21938756; PMCID: PMC6870517.
It is kind of interesting the implications of "making you feel less hungry" in terms of a general insensitivity to the bodies own signalling mechanisms, vs just a hyper convenient targeted approach that only strikes the hunger portion of the dopamine-reward mechanism.
I wonder if you can do a simple experiment between glp and non glp users where you try and measure various biological response to giving someone say $20?
Going further I wonder if it affects other responses like pain response. How long might you keep your hand on a plate warming up? I seem to remember that sort of experimental setup in my undergrad days of signing up for every psychology department experiment under the sun for beer money.
Reminds me of the movie Equilibrium. And we won't even get Gun Katas.
"But I being poor, have only my dreams. I lay my dreams upon your feet. Tread lightly, for you tread on my dreams."
Any plans to trial these types of drugs in the prison system?
They're FDA approved drugs, so it's a matter of when they're covered by any given prison's health plan. They're unlikely to be given off-label, But there's probably plenty of prisoners on GLPs at least for diabetes if not weight control.
Experimentation on prisoners is unethical
I only mean offer it to them for free so they don't have to sneak in with the assorted peptides and other compounds. Many body builders have already been using Retatrutide for a couple years for muscle definition even though it is not yet approved. I would be quite surprised if they were not already sneaking it into the prison system. Government funded, sourced and dosed should be somewhat safer than going to sketchy websites that require bitcoin and no guarantees of purity.
If I were a prison guard or warden I would be happy to encourage prisoners to use any compound that may improve their impulse control which is likely one of the root causes of their incarceration in the first place.
Tell that to the many prisoners who participated in and benefited from HIV and hepatitis vaccine trials. What a travesty it would have been if there were a blanket ban on prisoner research.
Research on prisoners is subject to stricter standards, though. From the HHS website:
> Research involving prisoners is permissible only if the research involves one or more of four permissible categories, or if the research meets the criteria described in an HHS Secretarial waiver that applies to certain epidemiological research [...]
> (i) the study of the possible causes, effects, and processes of incarceration, and of criminal behavior, and
> (ii) the study of prisons as institutional structures or of prisoners as incarcerated persons. [...]
> (iii) research on conditions particularly affecting prisoners as a class; [...]
> (iv) research on practices, either innovative or accepted, which have the intent and reasonable probability of improving the health or well-being of the subject. [...]
https://www.hhs.gov/ohrp/regulations-and-policy/guidance/faq...
There would be informed consent. We aren't the SS.
The SS's policy towards the interred was heavily inspired by the policies the United States was already famous for. We have a historically monstrous record of unethical medical testing against both interred and underprivileged populations.
Well, today in 2026 there would be informed consent.
Would you like to hear about treatment of prisoners in early middle age Europe?
Nothing wrong with making GLP-1s freely available to all who want them if it improves metabolic health, reduces addiction, reduces cancer and inflammation risk, etc. Side effects are known and data to date shows risks are low. Ship it to everyone who wants it imho and kick off the longitudinal study.
The aggregate potential benefit is so high and the risk and cost reasonably low. Certainly, no one should ever be forced to take it, or be experimented on without their explicit, informed consent (and "experimented on" in this context is "taking the GLP-1 already and we're just tracking the outcomes at scale").
Could be risky. Healthy prisoners might lead to a rise in 'I can fix him/her' complexes across the general population.
Who knows, maybe when healthy some of them could actually be fixed.
But does this drop in "aggression" also destroy good "assertiveness"?
In other words there's a concern of creating metaphorical "zombies" who lack a "force of will"
Honestly, I look forward to not having to worry in the back of my mind about having to deal with some unhinged person's "force of will" when I'm just trying to get groceries or pick my kid up from school. A calmer, more cooperative, less "assertive/aggressive" population is a good thing if that's really a possible outcome of these drugs.
Is there any merit to this concern, or did you just imagine it?
Semenza lol
Soma pills are within reach!
Pills that make you a vegetable because you don't want to eat vegetables instead of sweets and count calorie intake.
If it works by reducing “wanting” then it may change not only violent behavior but the flip side, attachment and love.
This is a known potential side-effect of these drugs. When I started them my doctor warned me about a possible lack of motivation. These drugs trigger your body's satiation mechanism (as I understand them–not a doctor) and that can apply to more things than just eating.
Are those really a flip side? Stoics wouldn't agree.